Description

Peptidox L is a stabilized and preservative-free solution of Acetyl Hexapeptide-8 in water and caprylyl glycol. Acetyl Hexapeptide-8 is a synthesized, acetylated oligopeptide, also known under the synonym Acetyl Hexapeptide-3. It is a non-toxic molecule that mimics the action of BoNTs (Botulinum neurotoxins used in Botox), revolutionary neurotoxins with remarkable anti-wrinkle activity.  This alternative inhibition of muscle contraction is due to the interference of the hexapeptide with the formation and/or stability of the protein complex that is required to drive Ca2+ – dependent exocytosis, namely the vesicular fusion (known as SNARE) complex. Notably, this peptide, however, did not exhibit in vivo oral toxicity nor primary irritation at high doses. Acetyl Hexapeptide-8, therefore, represents a medically safe, topical, and painless alternative to BoNTs in cosmetics. In anti-aging treatments, it reduces the appearance and development of wrinkles at the areas of the forehead and eyes locally and is reversible without the rigid mask effect of the mimics. Peptidox® L is a preservative-free solution with >= 0.05 % peptide content, stabilized with caprylyl glycol.

Properties: Anti-Wrinkle for face and eye area, skin elasticity enhancer

2 % Peptidox® L (cream) decreased wrinkle volume up to 34.28 % after 56 days, wrinkle area up to 32.61 %, and wrinkle ratio up to 33.35 % (overall >30.2 % more effective than benchmark)
– improves skin elasticity: 2 % Peptidox® L (cream) increased skin elasticity up to 10.03 % after 56 days (similar to benchmark)  and decreases wrinkle progression

Appearance: clear Solution

Standard Shelf Life: 24 months from the production date, in the original sealed containers (The delivered product might have shorter shelf life than standard). Acetyl Hexapeptide-8/3 should be stored in sealed containers at a dry, cool, and light-protected place at 2 – 8°C. Avoid freezing or excessive heat.

CAS-No: Aqua (7732-18-5), Caprylyl Glycol(1117-86-8), Acetyl Hexapeptide-8

EC-No: Aqua (231-791-2), Caprylyl Glycol(214-254-7), Acetyl Hexapeptide-8(926-238-3)

INCI Name: Aqua, Caprylyl Glycol, Acetyl Hexapeptide-8 (Acetyl Hexapeptide-3)  (Caprylyl Glycol at<= 0.5 %) (peptide content>= 0.05 %)

Use level and Method: 2 – 10% It should be blended into the water phase below 40°C.

Applications: Premium Anti-aging products, creams and lotions, face masks, gels, and ampoules

Country of Origin: China

Raw material source: Amino acids

Manufacture method: Acetyl hexapeptide-3 is produced synthetically from amino acids. It is a fragment of SNAP-25, a substrate of botulinum toxin (Botox).

Animal Testing: No    Vegan: Could be used

GMO: GMO-free, but not certified